circulatory system

| December 7, 2015

Fetal red blood cells carry a hemoglobin which has a mutation in the hemoglobin chains that reduces the affinity of 2,3-BPG for fetal hemoglobin. a) Based on what you know about the affinity of T-state and R-state of hemoglobin for oxygen, predict whether the binding affinity of oxygen of fetal hemoglobin will be higher or lower than for normal hemoglobin. Explain your answer. b) Will this mutation allow oxygen to be transported more efficiently or less efficiently by fetal hemoglobin when compared to normal hemoglobin?

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